Dizideki bazı konuk oyuncular; George Clooney, Brad Pitt, Tom Selleck, Susan Sarandon, Reese Witherspoon, Christina Applegate, Gary Oldman, Bruce Willis, Elle Macpherson, Anna Faris, Vinona Ryder, Denise Richards, Sean Penn, Alec Baldwin, Jon Lovitz, Julia Roberts, Robin Williams, Brooke Shields, Ben Stiller, Charlie Sheen, Rebecca Romjin, Selma Blair’dir.